Director, Center for Innovative Antimicrobial Therapy
Associate Professor of Medicine
Education & Training
Medical School – Nagoya University School of Medicine (Japan) – MD
Graduate School – Nagoya University School of Medicine (Japan) - PhD
Residency – St. Luke’s – Roosevelt Hospital Center – Internal Medicine
Fellowship – UPMC – Infectious Disease
Research
The mission of Dr. Doi's laboratory is to identify and investigate antimicrobial resistance of clinical concern among gram-negative bacterial pathogens. The areas of research include the genetic and molecular basis of emerging antimicrobial resistance mechanisms; the rapid diagnosis of resistance using phenotypic, genetic, and lipidomic approaches; and inhibitor-based drug discovery. Current efforts are focused on colistin resistance in Acinetobacter baumannii, a problematic healthcare-associated pathogen, and fosfomycin resistance in Escherichia coli, the predominant cause of urinary tract infection in both healthcare and community settings. The latter work has expanded into drug discovery effort aimed at reversing resistance using an inhibitor-based approach.
